Rabies Virus Severely Influences Host Protein during Terminal Stages of Infection

Rabies is one of the negligible infectious diseases of public health concern and is responsible for over 30, 000 deaths in Asia and Africa alone (Mani and Madhusudana, 2013). The disease is 100% preventable provided post-exposure prophylaxis (PEP) treatment consisting of vaccines and immunoglobulins is initiated timely. Despite this, it continues to pose a threat due to ignorance of people in management of animal bites and sparseness of medical resources. Besides, the clinical signs appear only when it reaches the central nervous system (CNS), after which it always proves to be fatal (Wang et al., 2005). Unfortunately, antè-mortem diagnostic tests are most often inconclusive and a negative result does not rule of infection. The problem is further compounded by absence of an effective treatment for rabies (Madhusudana and Sukumaran, 2008; Mani and Madhusudana, 2013). Management of ISSN: 2319-7706 Volume 4 Number 10 (2015) pp. 129-137 http://www.ijcmas.com